A crowded new school and a crazy class schedule is enough to make Izzy feel dizzy. It may be the first day of middle school, but as long as her best friends Allie Einstein and Charlie Darwin are by her side, Izzy knows it'll all be okay. However, first-day jitters take an icy turn when Izzy's old pal Marie Curie comes back to town. Instead of a warm welcome, Marie gives her former pal the cold shoulder. The problems pile up when the school's air-conditioning goes on the fritz and the temperature suddenly drops to near freezing. The adults don't seem to have a clue how to thaw out the school. Cold temperatures and a frigid friendship? Izzy has had enough of feeling like an absolute zero. She rallies the girls to use their brainpower and science smarts to tackle the school's chilly mystery ... and hopefully to fix a certain frozen friendship along the way. Will the girls succeed and become the heroes of Atom Middle School?